PHARMACOKINETICS相关论文
抗菌药物的药代动力学/药效动力学研究充分考虑宿主、病原体和药物三者的相互关系，反映抗菌药物疗效及不良反应与药物浓度变化之间......
Pharmacokinetics,distribution,and excretion of sodium oligomannate,a recently approved anti-Alzheime
The National Medical Products Administration has authorized sodium oligomannate for treating mild-to-moderate Alzheimer......
体外膜肺氧合（ECMO）作为一种可以替代肺脏和心脏功能的生命支持技术，在各种危重症呼吸、循环衰竭中的应用逐渐增多。由于自身严重疾病......
The 2020 Nobel Prize in Chemistry recognized CRISPR-Cas9,a super-selective and precise gene editing tool.CRISPR-Cas9 has......
Effect of Acute Pancreatitis on the Pharmacokinetics of Chinese Herbal Micron Liuhe Pill Ointment(微米
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Effect of Formula Compatibility on the Pharmacokinetics of Components from Dachengqi Decoction（大承气汤）
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Changes of Pharmacokinetics of 6,7-Dimethoxycoumarin in A Rat Model of Alpha-Naphthylisothiocyanate-
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Objective:To study the pharmacokinetics of puerarin (PUE) in Gegen Qinlian Decoction (葛根芩连汤,GQD),and the effects of......
Objective:To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib (Iressa(R)) and the o......
Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K adminis
Ginkgo diterpene lactones meglumine injection (GDLI) is a commercially available product used for neuroprotection.Howeve......
Radix Scutellaria is widely applied to the treatment of diabetes mellitus in China.Its main bioactive constituents conta......
Herein,the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nif......
Simultaneous quantification of chlorogenic acid and taurocholic acid in human plasma by LC-MS/MS and
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The present study was designed to develop a sensitive and selective specific high performance liquid chromatography (HPL......
Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ,
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LC/MS/MS determination and pharmacokinetic studies of six compounds in rat plasma following oral adm
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Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of
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An HPLC-MS/MS method for the quantitative determination of platycodin D in rat plasma and its applic
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With the advance in material science,silver nanoparticles(AgNPs)are modified by different surface coating.However,how th......
Miconazole is a broad spectrum topical azole antifungal agent.The drug has poor water solubility and gastrointestinal pe......
Enhanced Pharmacokinetics and Anti-Tumor Efficacy of PEGylated Liposomal Rhaponticin and Plasma Prot
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Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cult
Background: Praziquantel(PZQ)is an effective pesticide against monogeneans.Its pharmacokinetics in fish may be affected ......
Gender-related pharmacokinetic of mifepristone/metapristone and the corresponding mechanism research
Mifepristone(RU486)is marketed and used widely by women as an abortifacient,and used in clinical trials for psychotic de......
Development of chitosan-based nanoparticles for improving anti-cancer effects and bioavailability of
Mifepristone(RU486,MIF)acted as the progesterone receptor(PR)modulator has been widely used for emergency contraception ......
Given that the traditional methods of estimating pharmacokinetic parameters are constrained by the sensitivity of their ......
The pharmacokinetics of chelerythrine solution and chelerythrine liposomes after oral administration
Background and Aim: Chelerythrine (CHE) is a quaternary benzo[c]phenanthridine alkaloid which has many potent pharmacolo......
5-Fluroruracil (5FU) is used as a chemotherapeutic agent in modem medicine.However,due to its low solubility at physiolo......
Long-acting antiparasitic formulations are used widely because they help prevent and treat parasitic infections and redu......
Renal Fat-Poor Angiomyolipoma: Differentiation from Renal Cell Carcinoma using Pharmacokinetic Param
Objective: To evaluate the diagnostic performance of pharmacokinetic parameters (Ktrans & Ve) derived from dynamic contr......
目的 we design the study aiming at detecting the pharmacokinetic difference among gefitinib,icotinib,erlotinib,and OSI-4......
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Influence of SLCO1B3 genetic polymorphisms on the incidence of adverse effects and trough plasma con
Background: Imatinib(Marketed as Glivec in USA and Gleevec in Europe)is a tyrosine kinase inhibitor(TKI),commonly used a......
Rapid and simultaneous determination of Imatinib and its main metabolite N-demethyl-Imatinib in huma
Imatinib(STI571)is a successful tyrosine kinase inhibitor which is applied to gastrointestinal stromal tumor(GIST)and ch......
Quantitative determination of four Sudan dyes in rat plasma with solid-phase extraction and UFLC-MS/
OBJECTIVE To develop and validate for the simultaneous determination of four Sudan dyes (Sudan Ⅰ , Sudan Ⅱ, Sudan Ⅲ, ......
Purpose: The effect of single and multiple doses of piperine on the bioavailability and pharmacokinetics of curcumin was......
Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Qishe Pill in Healthy Chinese Subject
To assess pharmacokinetics, pharmacodynamics, tolerability and safety of oral medication of Qishe Pill, a compound tradi......
Advances in the study of pharmacokinetics of epidermal growth factor receptor-tyrosine kinase inhibi
The receptor tyrosine kinases, including the EGFR, have been major targets for anticancer therapy since they are abundan......
Mass balance study, in which the radionuclide labeling technique can be used to obtain more detailed pharmacokinetic dat......
Simultaneous determination of long acting LHRH antagonists and its application to high-throughput ph
Aim: Long acting luteinizing hormone-releasing hormone (LHRH) antagonists designed to be protease-resistant were a serie......
HPLC assay validation for KCNQ/M-channel opener QO58-lysin in rat plasma and Its application to phar
The voltage-gated KCNQ/M-potassium channels play a principal role in controlling neuronal excitability.Mutations or inhi......
Determination of lapachol by liquid chromatographic-mass spectrometry and the application to pharmac
Aim: To study the quantification methods and pharmacokinetic application of lapachol.Methods: A sensitive and specific h......
Pharmacokinetics of peramivir trihydrate and sodium chloride injection in Chinese healthy volunteers
Aim: To study the pharmacokinetics of peramivir trihydrate and sodium chloride injection in Chinese healthy volunteers.M......
Title-Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization:Comparative pha
Apocynin,a potent inhibitor of NADPH-oxidase,was widely studied for activities in diseases such as inflammation-mediated......
A novel PVP coated norcantharidin-chitosan nanoparticles (PVP-NCTD-NPs) formulation with an average particle size of 140......
Over the last decades, the formulation of drugs as nanocrystals has successfully evolved into a mature drug delivery str......
Pharmacokinetics and bioavailability of Chlorogenic acid from LoniceraeJaponicaeFlos following diffe
OBJECTIVE Chlorogenic acid (ChA) is proposed as one of the main bioactive compounds ofLoniceraeJaponicaeFlos (LJF).To st......
